| Date | Home | Away | Result |
|---|---|---|---|
| 13/03/25 17:45 | Athletic Bilbao | AS Roma | 3-1 |
| 13/03/25 17:45 | Lazio Rom | Viktoria Plzen | 1-1 |
| 13/03/25 17:45 | Olympiakos Piräus | FK Bodö/Glimt | 2-1 |
| 13/03/25 17:45 | Eintracht Frankfurt | Ajax Amsterdam | 4-1 |
| 13/03/25 20:00 | Tottenham Hotspur | AZ Alkmaar | 3-1 |
| 13/03/25 20:00 | Manchester United | Real Sociedad | 4-1 |
| 13/03/25 20:00 | Olympique Lyon | FCSB Bukarest | 4-0 |
| 13/03/25 20:00 | Glasgow Rangers | Fenerbahce Istanbul | 3-4a.PSO |