| Date | Home | Away | Result |
|---|---|---|---|
| 11/12/24 15:30 | Fenerbahce Istanbul | Athletic Bilbao | 0-2 |
| 12/12/24 17:45 | Malmö FF | Galatasaray Istanbul | 2-2 |
| 12/12/24 17:45 | AS Roma | Sporting Braga | 3-0 |
| 12/12/24 17:45 | PAOK Saloniki | Ferencvaros Budapest | 5-0 |
| 12/12/24 17:45 | Olympiakos Piräus | FC Twente Enschede | 0-0 |
| 12/12/24 17:45 | Royale Union Saint-Gilloise | OGC Nice | 2-1 |
| 12/12/24 17:45 | PFC Ludogorets Razgrad | AZ Alkmaar | 2-2 |
| 12/12/24 17:45 | Viktoria Plzen | Manchester United | 1-2 |
| 12/12/24 17:45 | 1899 Hoffenheim | FCSB Bukarest | 0-0 |
| 12/12/24 20:00 | Glasgow Rangers | Tottenham Hotspur | 1-1 |
| 12/12/24 20:00 | FC Porto | FC Midtjylland | 2-0 |
| 12/12/24 20:00 | Slavia Prag | RSC Anderlecht | 1-2 |
| 12/12/24 20:00 | Ajax Amsterdam | Lazio Rom | 1-3 |
| 12/12/24 20:00 | Maccabi Tel Aviv | Rigas Futbola Skola | 2-1 |
| 12/12/24 20:00 | Real Sociedad | Dynamo Kiew | 3-0 |
| 12/12/24 20:00 | Olympique Lyon | Eintracht Frankfurt | 3-2 |
| 12/12/24 20:00 | FK Bodö/Glimt | Besiktas Istanbul | 2-1 |
| 12/12/24 20:00 | IF Elfsborg Boras | Qarabag | 1-0 |